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Highlights |
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A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic CanadaTERC variant telomere biology disorders (TBDs) are a rare, heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as many different phenotypes.
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Opioid Use in Adults With Sickle Cell Disease Hospitalized During Vaso-Occlusive Crisis: A Systematic ReviewWhile pain is the hallmark of sickle cell disease (SCD), healthcare personnel are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis (VOC).
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A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid LeukemiaResistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.
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Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic LeukemiaWe conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.
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Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual DiseaseAlthough rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.
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Viewpoints |
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| Featured |
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| Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis | |||
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 Schnitzler’s Syndrome: A Diagnostic Consideration in Evaluating the Constellation of Monoclonal Gammopathy and Chronic Urticaria |
Current Issue |
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Vol. 10, No. 3, Jun 2021
Table of Contents
Review
| Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma | Abstract HTML PDF |
Hamid Ehsan, Ahsan Wahab, Zunairah Shah, Muhammad Khawar Sana , Adeel Masood, Abdul Rafae, Hamza Hashmi
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89-97 |
| doi: https://doi.org/10.14740/jh844 |
Original Article
| Does ABO Blood Groups Affect Outcomes in Hospitalized COVID-19 Patients? | Abstract HTML PDF Suppl1 Suppl2 |
| Gagan Kumar, Rahul Nanchal, Martin Hererra, Ankit Sakhuja, Dhaval Patel, Mark Meersman, Drew Dalton, Achuta Kumar Guddati | 98-105 |
| doi: https://doi.org/10.14740/jh824 |
| Essential Thrombocythemia in Children: A Retrospective Study | Abstract HTML PDF |
| Muhammed Ameen, Khawar Siddiqui, Saadiya Khan, Mahasen Saleh, Abdullah Al-Jefri, Abdulrahman Al-Musa | 106-113 |
| doi: https://doi.org/10.14740/jh822 |
| Comparative Effectiveness of a Six-Week Treatment Course of Vitamin D2 and D3 in Children With Sickle Cell Anemia in Steady State With Hypovitaminosis D: A Randomized Clinical Trial | Abstract HTML PDF |
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Motunrayo Oluwabukola Adekunle, Adeyemi Oluwaseun Dada, Fidelis Olisamedua Njokanma, Adaobi Uzoamaka Solarin, Barakat Adeola Animasahun, Moriam Omolola Lamina
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114-122 |
| doi: https://doi.org/10.14740/jh817 |
Short Communication
| A Description of the Type, Frequency and Severity of Infections Among Sixteen Patients Treated for T-Cell Lymphoma | Abstract HTML PDF Suppl1 |
| Tina Ko, Crystal Seah, Michael Gilbertson, Zoe McQuilten, Stephen Opat, Claire Dendle | 123-129 |
| doi: https://doi.org/10.14740/jh838 |
Case Report
| A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic Canada | Abstract HTML PDF |
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Amye M. Harrigan, Shelley MacDonald, Bruce Crooks, Sarah Dyack, Amy M. Trottier
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130-135 |
| doi: https://doi.org/10.14740/jh826 |
| Early Onset Neutropenia due to Rituximab Therapy in Mantle Cell Lymphoma: A Case Report | Abstract HTML PDF |
| Blessie Elizabeth Nelson, Shelby Tipton, Rohit Venkatesan | 136-138 |
| doi: https://doi.org/10.14740/jh814 |
| A Novel Case of Leflunomide-Induced Thrombotic Thrombocytopenic Purpura | Abstract HTML PDF |
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Misty Dawn Shields, William Paul Skelton, Damian A. Laber, Michael Verbosky, Noman Ashraf
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139-142 |
| doi: https://doi.org/10.14740/jh837 |
| Schnitzler’s Syndrome: A Diagnostic Consideration in Evaluating the Constellation of Monoclonal Gammopathy and Chronic Urticaria | Abstract HTML PDF |
| Jyothika Mamadgi, Laila Babar, Rama Bhagavatula, Santhosh Sadashiv, Kossivi Dantey, Mariya Apostolova | 143-146 |
| doi: https://doi.org/10.14740/jh800 |