Journal of Hematology

Roberto Castelli, MD, PhD, Professor, Division of Internal Medicine, Department of Biomedical and Clinical Sciences, University of Milan, Italy Read more...

ISSN 1927-1212 print | ISSN 1927-1220 online | Bimonthly (from 2021) | Open Access | Aims and Scope

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  • A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia

    Resistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.

  • Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia

    We conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.

  • Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

    Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.

  • Impact of Opioid Use in Hematological Malignancies: Clinical, Immunological and Concomitant Aspects

    Opioid agents play a unique role in pain and symptom management for cancer patients. Research shows that opiate use, especially when associated with underlying cancer, has significant effects on hematological parameters.

  • Outcomes of Reduced Frequency Dosing of Ibrutinib in Chronic Lymphocytic Leukemia Patients Following Complete or Partial Remission: A Pilot Study

    Ibrutinib is a Bruton’s tyrosine kinase inhibitor that has shown to be a superior choice in the treatment of chronic lymphocytic leukemia (CLL) and a simple, oral alternative to other chemoimmunotherapies.







The Impact of Preoperative Intravenous Iron Therapy on Perioperative Outcomes in Cardiac Surgery: A Systematic Review
Anemia is common in cardiac surgery affecting 25-40% of patients and associated with increased blood transfusions, morbidity, mortality, and higher hospital costs. Higher rates of stroke, acute renal injury, and total number of adverse postoperative outcomes have also been reported to be associated with preoperative anemia. Read the Full Text

Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis
Patients presenting with acute myeloid leukemia (AML) at diagnosis are at high risk of severe complications and death, particularly with high white blood cell (WBC) count. In this retrospective study, we evaluate interest of early and systematic support in the intensive care unit (ICU) for AML with hyperleukocytosis (AML-HL) at diagnosis. Read the Full Text

Image of the Issue

Bone Marrow Involvement by Aggressive B Cell Lymphoma Undetected by Aspirate Immunophenotyping
Staging for newly diagnosed lymphoma is an essential diagnostic step aimed at not only estimating prognosis but also refining the ensuing therapeutic pathway. Bone marrow is routinely sampled for this reason. Morphological assessment of the bone marrow aspirate and biopsy remains the gold standard approach. Full Text

Current Issue


Vol. 10, No. 1, Feb 2021

Table of Contents

Original Article

A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia Abstract HTML PDF
Mary Beth Seegars, Ryan Woods, Leslie R. Ellis, Rupali Roy Bhave, Dianna S. Howard, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L. Powell, Timothy S. Pardee 1-7
Use of a Mobile Intermittent Pneumatic Compression Device (Vekroosan) in Mobile Patients With Chronic Venous Disease Abstract HTML PDF
Raj Ramakrishna, William Alexander, Lina Baytieh 8-13

Case Report

Bone Marrow Involvement by Aggressive B Cell Lymphoma Undetected by Aspirate Immunophenotyping Abstract HTML PDF
Habib Moshref Razavi 14-17
Delayed Hemolytic Transfusion Reaction in a Patient With Sickle Cell Disease and the Role of the Classical Complement Pathway: A Case Report Abstract HTML PDF
Pamela S. Hair, Timothy P. Heck, Daniel T. Carr, Katherine D. Watson, Jessica Price, Neel K. Krishna, Kenji M. Cunnion, William C. Owen 18-21
Tamoxifen Therapy for Recurrent Mucosal Bleeding in Hereditary Hemorrhagic Telangiectasia Abstract HTML PDF
Stephanie Yung, Julie-Anne Bell, Jim Brooker 22-24
Histologic Transformation in an Untreated Waldenstrom’s Macroglobulinemia After 14 Years: Case Report and Review of the Literature Abstract HTML PDF
Elizabeth B. Elimimian, Nadeem Bilani, Maria J. Diacovo, Skirmante Sirvaitis, Chieh Lin Fu 25-29
Spontaneous Tumor Lysis Syndrome: A Rare Presentation in Plasmablastic Lymphoma Abstract HTML PDF
Joana Infante, Andre Casado, Antonio Almeida, Antonio Messias 30-34

Letter to the Editor

Similar Outcomes in Early-Failure Steroid-Dependent Compared to Upfront Steroid Refractory Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplant Abstract HTML PDF
Dilan A. Patel, Karina A. Mendoza, Heidi Chen, Brian G. Engelhardt, Bipin N. Savani, Stacey A. Goodman, Jeremy Warner, Adetola A. Kassim, Michael Byrne, Wichai Chinratanalab, John P. Greer, Carole Hunt, Madan Jagasia 35-39

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                    
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