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Highlights |
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A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic CanadaTERC variant telomere biology disorders (TBDs) are a rare, heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as many different phenotypes.
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Opioid Use in Adults With Sickle Cell Disease Hospitalized During Vaso-Occlusive Crisis: A Systematic ReviewWhile pain is the hallmark of sickle cell disease (SCD), healthcare personnel are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis (VOC).
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A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid LeukemiaResistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.
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Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic LeukemiaWe conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.
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Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual DiseaseAlthough rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.
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Viewpoints |
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| Featured |
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| Validation of a Modified Version of the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score | |||
Key Clinical Image |
 Progressive Multifocal Leukoencephalopathy After Chimeric Antigen Receptor T-Cell Therapy for Recurrent Non-Hodgkin Lymphoma |
Current Issue |
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Vol. 10, No. 5, Oct 2021
Table of Contents
Original Article
| Validation of a Modified Version of the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score | Abstract HTML PDF |
| Blake T. Langlais, Gina L. Mazza, Heidi E. Kosiorek, Jeanne Palmer, Ruben Mesa, Amylou C. Dueck | 207-211 |
| doi: https://doi.org/10.14740/jh914 |
Case Report
| Progressive Multifocal Leukoencephalopathy After Chimeric Antigen Receptor T-Cell Therapy for Recurrent Non-Hodgkin Lymphoma | Abstract HTML PDF |
Jared T. Ahrendsen , Kartik Sehgal, Sasmit Sarangi, Erik J. Uhlmann, Hemant Varma, Jon Arnason, David Avigan
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212-216 |
| doi: https://doi.org/10.14740/jh903 |
| Acute Respiratory Distress Syndrome in a Patient With Acute Promyelocytic Leukemia: Overlapping Between Differentiation Syndrome and COVID-19 | Abstract HTML PDF |
| Jingrui Sui, Daniel Kelmenson, Shimin Hu, Liyun Cao | 217-220 |
| doi: https://doi.org/10.14740/jh904 |
| Hemolytic Anemia Complicating COVID-19 Infection | Abstract HTML PDF |
| Abeer N. AbouYabis, Grace Thompson Bell | 221-227 |
| doi: https://doi.org/10.14740/jh906 |
| Non-Invasive Prenatal Testing Leading to Detection of Asymptomatic Acute Myeloid Leukemia in a 30-Year-Old Patient: A Case Report | Abstract HTML PDF |
| Sterre P.E. Willems, Marianne Stenstra, Mojca Jongen-Lavrencic, Michelle E.M.H. Westerhuis, H. Berna Beverloo, Gerard Vreugdenhil | 228-231 |
| doi: https://doi.org/10.14740/jh908 |