Journal of Hematology

Farhad Ravandi, MD, Professor
Janiece and Stephen A. Lasher Professor of Medicine
Chief, Section of Acute Myeloid Leukemia
Department of Leukemia
The University of Texas MD Anderson Cancer Center, Texas, USA  Read more...

ISSN 1927-1212 print | ISSN 1927-1220 online | Bimonthly | Open Access | Aims and Scope

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  • A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic Canada

    TERC variant telomere biology disorders (TBDs) are a rare, heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as many different phenotypes.

  • Opioid Use in Adults With Sickle Cell Disease Hospitalized During Vaso-Occlusive Crisis: A Systematic Review

    While pain is the hallmark of sickle cell disease (SCD), healthcare personnel are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis (VOC).

  • A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia

    Resistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.

  • Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia

    We conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.

  • Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

    Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.







Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma
Biomarker-driven targeted therapies have been an area of exploration for innovative therapeutic options in oncology. B-cell lymphoma-2 (BCL-2) protein is an anti-apoptotic protein expressed on the clonal plasma cells in patients with multiple myeloma (MM). MM subsets with t (11;14) have overexpression of BCL-2 and can benefit from venetoclax (VEN) when used either alone or in combination with other chemotherapeutic agents with an overall response rate (ORR) ranging from 40% to 100%. Read the Full Text

Validation of a Modified Version of the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score
Patients with myeloproliferative neoplasms (MPNs) suffer from chronic and progressive symptom burden. MPN trials capturing patient-reported symptoms routinely administer the MPN Symptom Assessment Form (SAF). The MPN-10 assesses 10 of the most clinically relevant symptoms, including fatigue and generates a Total Symptom Score (TSS). Read the Full Text

Key Clinical Image

Progressive Multifocal Leukoencephalopathy After Chimeric Antigen Receptor T-Cell Therapy for Recurrent Non-Hodgkin Lymphoma
Chimeric antigen receptor (CAR) T-cell therapy targeting cluster of differentiation (CD)19 has had a transformative impact on patient outcomes in a subset of patients with relapsed/refractory non-Hodgkin lymphoma. We present a patient with refractory large B-cell lymphoma in complete remission for 2 years following treatment with CD19-targeted CAR T-cell therapy, who presented with 2 weeks of progressive aphasia. Imaging revealed a left occipital brain lesion and biopsy demonstrated features diagnostic of progressive multifocal leukoencephalopathy. Full Text

Current Issue


Vol. 10, No. 5, Oct 2021

Table of Contents

Original Article

Validation of a Modified Version of the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score Abstract HTML PDF
Blake T. Langlais, Gina L. Mazza, Heidi E. Kosiorek, Jeanne Palmer, Ruben Mesa, Amylou C. Dueck 207-211

Case Report

Progressive Multifocal Leukoencephalopathy After Chimeric Antigen Receptor T-Cell Therapy for Recurrent Non-Hodgkin Lymphoma Abstract HTML PDF
Jared T. Ahrendsen, Kartik Sehgal, Sasmit Sarangi, Erik J. Uhlmann, Hemant Varma, Jon Arnason, David Avigan 212-216
Acute Respiratory Distress Syndrome in a Patient With Acute Promyelocytic Leukemia: Overlapping Between Differentiation Syndrome and COVID-19 Abstract HTML PDF
Jingrui Sui, Daniel Kelmenson, Shimin Hu, Liyun Cao 217-220
Hemolytic Anemia Complicating COVID-19 Infection Abstract HTML PDF
Abeer N. AbouYabis, Grace Thompson Bell 221-227
Non-Invasive Prenatal Testing Leading to Detection of Asymptomatic Acute Myeloid Leukemia in a 30-Year-Old Patient: A Case Report Abstract HTML PDF
Sterre P.E. Willems, Marianne Stenstra, Mojca Jongen-Lavrencic, Michelle E.M.H. Westerhuis, H. Berna Beverloo, Gerard Vreugdenhil 228-231

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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