Journal of Hematology

Farhad Ravandi, MD, Professor
Janiece and Stephen A. Lasher Professor of Medicine
Chief, Section of Acute Myeloid Leukemia
Department of Leukemia
The University of Texas MD Anderson Cancer Center, Texas, USA  Read more...

ISSN 1927-1212 print | ISSN 1927-1220 online | Bimonthly | Open Access | Aims and Scope

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  • Harnessing the Immune System: An Effective Way to Manage Diffuse Large B-Cell Lymphoma

    Diffuse large B-cell lymphoma (DLBCL) is a heterogenous hematological disorder with malignant potential controlled by immunological characteristics of the tumor microenvironment. Rapid breakthrough in the molecular pathways has made immunological approaches the main anchor in the management of DLBCL, with or without chemotherapeutic agents.

  • Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis

    Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy. ICI therapy is generally better tolerated than cytotoxic chemotherapy; however, hematological adverse events (AEs) have not been fully analyzed.

  • Mature Type T-Lymphoblastic Leukemia/Lymphoma Presenting With Isolated Central Nervous System Symptomatology in a Patient With Giant Cell Arteritis on Long-Term Steroid Treatment

    T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) is a malignancy comprised of T-lymphoblasts that can present as one of four clinical subtypes (pro-T, pre-T, cortical T, and mature T).

  • Acute Myeloid Leukemia Following Myeloproliferative Neoplasms: A Review of What We Know, What We Do Not Know, and Emerging Treatment Strategies

    Acute myeloid leukemia (AML) arising from myeloproliferative neoplasms (MPNs) represents a small subtype of secondary AML (sAML). This entity is well known to be associated with poor responses to available treatment options and dismal outcomes.

  • Treatment of Light Chain Deposition Disease: A Systematic Review

    Light chain deposition disease (LCDD) is a rare hematologic disorder that can affect any organ but predominantly involves the kidneys. Existing literature is limited to case reports and small single-center retrospective series, explaining the lack of any treatment algorithms and management guidelines for patients with this disorder.







Real-World Data of Crizanlizumab in Sickle Cell Disease: A Single-Center Analysis
Crizanlizumab was approved by the United States Food and Drug Administration agency in 2019 for decreasing vaso-occlusive events (VOEs) in sickle cell disease (SCD). Data regarding the use of crizanlizumab in the real-world setting are limited. Full Text

Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia
Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton’s tyrosine kinase inhibitor (BTKi) ibrutinib. Full Text

Key Clinical Image

Sickle Cell Trait: Is It Always Benign?
Sickle cell disease is a well-known homozygous inherited hemoglobinopathy that causes vaso-occlusive phenomena and chronic hemolysis. Vaso-occlusion results in sickle cell crisis and can eventually lead to complications involving multiple organ systems. However, the heterozygous counterpart, sickle cell trait (SCT) has less clinical significance as these patients are generally asymptomatic. Full Text

Current Issue


Vol. 12, No. 4, Aug 2023

Table of Contents


Harnessing the Immune System: An Effective Way to Manage Diffuse Large B-Cell Lymphoma Abstract HTML PDF
Nathan Visweshwar, Juan Felipe Rico, Robert Killeen, Arumugam Manoharan 145-160

Original Article

Could the Crosstalk Between Myeloid-Derived-Suppressor Cells and Regulatory T Cells Have a Role in Beta-Thalassemia? Abstract HTML PDF
Asmaa M. Zahran, Omnia El-Badawy, Eman R. Badawy, Khalid I. Elsayh, Eman F. Gad, Khaled Saad, Khalid Hashim Mahmoud, Amira Elhoufey, Hamad Ghaleb Dailah, Marwa Ghazaly 161-169

Short Communication

Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia Abstract HTML PDF Suppl1
Maria Andersson, Jinghua Wu, David Wullimann, Yu Gao, Mikael Aberg, Sandra Muschiol, Katie Healy, Sabrina Naud, Gordana Bogdanovic, Marzia Palma, Hakan Mellstedt, Puran Chen, Hans-Gustaf Ljunggren, Lotta Hansson, Margaret Sallberg Chen, Marcus Buggert, Hanna M. Ingelman-Sundberg, Anders Osterborg 170-175

Case Report

Reduced-Intensity Anthracycline-Free Chemoimmunotherapy in Elderly Patients With Newly Diagnosed or Relapsed Diffuse Large B-Cell Lymphoma Abstract HTML PDF
Binoy Yohannan, Adan Rios 176-186
Leukostasis With Isolated Central Nervous System Involvement in Chronic Phase of Chronic Myelogenous Leukemia Abstract HTML PDF
Won Jin Jeon, Suhani Dalal, Jin Hyun Moon, Bowon Joung, Michael Nguyen, Dani Castillo, Jessica Hudson, Kiwon Park, Ravi Raghavan, Mojtaba Akhtari, Ami Patel 187-196

Letter to the Editor

Hemolytic Anemia Requiring Splenectomy in Leigh-Like Syndrome due to the Variant m.10191T>C in MT-ND3 Abstract HTML PDF
Shaundra M. Newstead, Josef Finsterer 197-200

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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