Journal of Hematology

Farhad Ravandi, MD, Professor
Janiece and Stephen A. Lasher Professor of Medicine
Chief, Section of Acute Myeloid Leukemia
Department of Leukemia
The University of Texas MD Anderson Cancer Center, Texas, USA  Read more...

ISSN 1927-1212 print | ISSN 1927-1220 online | Bimonthly | Open Access | Aims and Scope

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  • A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic Canada

    TERC variant telomere biology disorders (TBDs) are a rare, heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as many different phenotypes.

  • Opioid Use in Adults With Sickle Cell Disease Hospitalized During Vaso-Occlusive Crisis: A Systematic Review

    While pain is the hallmark of sickle cell disease (SCD), healthcare personnel are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis (VOC).

  • A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia

    Resistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.

  • Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia

    We conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.

  • Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

    Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.







Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma
Biomarker-driven targeted therapies have been an area of exploration for innovative therapeutic options in oncology. B-cell lymphoma-2 (BCL-2) protein is an anti-apoptotic protein expressed on the clonal plasma cells in patients with multiple myeloma (MM). MM subsets with t (11;14) have overexpression of BCL-2 and can benefit from venetoclax (VEN) when used either alone or in combination with other chemotherapeutic agents with an overall response rate (ORR) ranging from 40% to 100%. Read the Full Text

Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis
Patients presenting with acute myeloid leukemia (AML) at diagnosis are at high risk of severe complications and death, particularly with high white blood cell (WBC) count. In this retrospective study, we evaluate interest of early and systematic support in the intensive care unit (ICU) for AML with hyperleukocytosis (AML-HL) at diagnosis. Read the Full Text

Key Clinical Image

Schnitzler's Syndrome: A Diagnostic Consideration in Evaluating the Constellation of Monoclonal Gammopathy and Chronic Urticaria
Schnitzler's syndrome is a rare clinical entity characterized by intermittent, non-pruritic urticarial rash, fevers, arthralgias, myalgias and monoclonal gammopathy, most commonly of the immunoglobulin M (IgM) subtype. Schnitzler's syndrome should be considered in the differential diagnosis of fever of unknown origin. We report a case of a 56-year-old healthy Caucasian female, who initially presented to the primary care physician's office with complaints of severe generalized fatigue and myalgias involving thighs and calves. Full Text

Current Issue


Vol. 10, No. 4, Aug 2021

Table of Contents


Current Updates on the Management of AL Amyloidosis Abstract HTML PDF
Marwa Elsayed, Sara Usher, Muhammad Hamza Habib, Nausheen Ahmed, Jawad Ali, Madeline Begemann, Syed Ahmed Shabbir, Leila Shune, Jaffar Al-Hilli, Furha Cossor, Brett W. Sperry, Shahzad Raza 147-161

Original Article

Incidence of Venous Thromboembolism and Effect of Anticoagulant Dosing in Hospitalized COVID-19 Patients Abstract HTML PDF Suppl1 Suppl2 Suppl3 Suppl4 Suppl5 Suppl6
Gagan Kumar, Dhaval Patel, Tariq Odeh, Erine Rojas, Ankit Sakhuja, Mark Meersman, Drew Dalton, Rahul Nanchal, Achuta Kumar Guddati 162-170
Risk Factors in Hospitalized Patients for Heparin-Induced Thrombocytopenia by Real World Database: A New Role for Primary Hypercoagulable States Abstract HTML PDF Suppl1
Jasmeet Kaur, Camelia Arsene, Sumeet Kumar Yadav, Olusola Ogundipe, Ambreen Malik, Anupam Ashutosh Sule, Geetha Krishnamoorthy 171-177
Azithromycin Reduces Markers of Vascular Damage in Pediatric Patients With Sickle Cell Disease Abstract HTML PDF Suppl1
Peter N. Uchakin, Vishwas S. Sakhalkar, Francis C. Dane, Olga N. Uchakina, Jatayah N. Sheed, William T. Uphouse, Om V. Sakhalkar 178-186
Treatment Outcomes and Survival Patterns of Asian Patients With Relapsed/Refractory Mantle Cell Lymphoma Abstract HTML PDF Suppl1 Suppl2 Suppl3 Suppl4 Suppl5
Jing Yuan Tan, Tian Yu Qiu, Jianbang Chiang, Ya Hwee Tan, Valerie Shiwen Yang, Esther Wei Yin Chang, Eileen Poon, Nagavalli Somasundaram, Mohamad Farid, Miriam Tao, Soon Thye Lim, Jason Yongsheng Chan 187-195

Short Communication

Platelet Aggregation Assays Do Not Reliably Diagnose Platelet Delta Granule Storage Pool Deficiency Abstract HTML PDF
William T. Gunning, Lorene Yoxtheimer, Mary R. Smith 196-201

Case Report

Severe Vitamin B12 Deficiency Mimicking Microangiopathic Hemolytic Anemia Abstract HTML PDF
Ramzi Hassouneh, Steve Shen, Olivia Lee, Rachel A. Hart, Logan P. Rhea, Patrick Fadden 202-205

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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