Journal of Hematology

Farhad Ravandi, MD, Professor
Janiece and Stephen A. Lasher Professor of Medicine
Chief, Section of Acute Myeloid Leukemia
Department of Leukemia
The University of Texas – MD Anderson Cancer Center, Texas, USA   Read more...

ISSN 1927-1212 print | ISSN 1927-1220 online | Bimonthly | Open Access | Aims and Scope

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  • A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic Canada

    TERC variant telomere biology disorders (TBDs) are a rare, heterogenous group of disorders that arise from germline variants in TERC, a gene that encodes for the RNA component of telomerase. Variants in TERC lead to accelerated telomere attrition and can manifest as many different phenotypes.

  • Opioid Use in Adults With Sickle Cell Disease Hospitalized During Vaso-Occlusive Crisis: A Systematic Review

    While pain is the hallmark of sickle cell disease (SCD), healthcare personnel are often ill-equipped to adequately treat patients who present in vaso-occlusive crisis (VOC).

  • A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia

    Resistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities.

  • Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia

    We conducted a phase 2 trial involving patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Patients were treated with ofatumumab with fresh frozen plasma (FFP) used as a source of complement replacement.

  • Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease

    Although rare, spontaneous remission (SR) of acute myeloid leukemia (AML) has been reported in the literature, the underlying mechanisms driving remission remain unknown. However, it is most commonly associated with a preceding severe infection.







Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma
Biomarker-driven targeted therapies have been an area of exploration for innovative therapeutic options in oncology. B-cell lymphoma-2 (BCL-2) protein is an anti-apoptotic protein expressed on the clonal plasma cells in patients with multiple myeloma (MM). MM subsets with t (11;14) have overexpression of BCL-2 and can benefit from venetoclax (VEN) when used either alone or in combination with other chemotherapeutic agents with an overall response rate (ORR) ranging from 40% to 100%. Read the Full Text

Reduce Mortality and Morbidity in Acute Myeloid Leukemia With Hyperleukocytosis With Early Admission in Intensive Care Unit: A Retrospective Analysis
Patients presenting with acute myeloid leukemia (AML) at diagnosis are at high risk of severe complications and death, particularly with high white blood cell (WBC) count. In this retrospective study, we evaluate interest of early and systematic support in the intensive care unit (ICU) for AML with hyperleukocytosis (AML-HL) at diagnosis. Read the Full Text

Image of the Issue

Schnitzler’s Syndrome: A Diagnostic Consideration in Evaluating the Constellation of Monoclonal Gammopathy and Chronic Urticaria
Schnitzler’s syndrome is a rare clinical entity characterized by intermittent, non-pruritic urticarial rash, fevers, arthralgias, myalgias and monoclonal gammopathy, most commonly of the immunoglobulin M (IgM) subtype. Schnitzler’s syndrome should be considered in the differential diagnosis of fever of unknown origin. We report a case of a 56-year-old healthy Caucasian female, who initially presented to the primary care physician’s office with complaints of severe generalized fatigue and myalgias involving thighs and calves. Full Text

Current Issue


Vol. 10, No. 3, Jun 2021

Table of Contents


Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma Abstract HTML PDF
Hamid Ehsan, Ahsan Wahab, Zunairah Shah, Muhammad Khawar Sana, Adeel Masood, Abdul Rafae, Hamza Hashmi 89-97

Original Article

Does ABO Blood Groups Affect Outcomes in Hospitalized COVID-19 Patients? Abstract HTML PDF Suppl1 Suppl2
Gagan Kumar, Rahul Nanchal, Martin Hererra, Ankit Sakhuja, Dhaval Patel, Mark Meersman, Drew Dalton, Achuta Kumar Guddati 98-105
Essential Thrombocythemia in Children: A Retrospective Study Abstract HTML PDF
Muhammed Ameen, Khawar Siddiqui, Saadiya Khan, Mahasen Saleh, Abdullah Al-Jefri, Abdulrahman Al-Musa 106-113
Comparative Effectiveness of a Six-Week Treatment Course of Vitamin D2 and D3 in Children With Sickle Cell Anemia in Steady State With Hypovitaminosis D: A Randomized Clinical Trial Abstract HTML PDF
Motunrayo Oluwabukola Adekunle, Adeyemi Oluwaseun Dada, Fidelis Olisamedua Njokanma, Adaobi Uzoamaka Solarin, Barakat Adeola Animasahun, Moriam Omolola Lamina 114-122

Short Communication

A Description of the Type, Frequency and Severity of Infections Among Sixteen Patients Treated for T-Cell Lymphoma Abstract HTML PDF Suppl1
Tina Ko, Crystal Seah, Michael Gilbertson, Zoe McQuilten, Stephen Opat, Claire Dendle 123-129

Case Report

A Case Series of TERC Variant Telomere Biology Disorders in Unrelated Families From Atlantic Canada Abstract HTML PDF
Amye M. Harrigan, Shelley MacDonald, Bruce Crooks, Sarah Dyack, Amy M. Trottier 130-135
Early Onset Neutropenia due to Rituximab Therapy in Mantle Cell Lymphoma: A Case Report Abstract HTML PDF
Blessie Elizabeth Nelson, Shelby Tipton, Rohit Venkatesan 136-138
A Novel Case of Leflunomide-Induced Thrombotic Thrombocytopenic Purpura Abstract HTML PDF
Misty Dawn Shields, William Paul Skelton, Damian A. Laber, Michael Verbosky, Noman Ashraf 139-142
Schnitzler’s Syndrome: A Diagnostic Consideration in Evaluating the Constellation of Monoclonal Gammopathy and Chronic Urticaria Abstract HTML PDF
Jyothika Mamadgi, Laila Babar, Rama Bhagavatula, Santhosh Sadashiv, Kossivi Dantey, Mariya Apostolova 143-146

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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