Role of Venetoclax in the Treatment of Relapsed and Refractory Multiple Myeloma

Hamid Ehsan, Ahsan Wahab, Zunairah Shah, Muhammad Khawar Sana, Adeel Masood, Abdul Rafae, Hamza Hashmi

Abstract


Biomarker-driven targeted therapies have been an area of exploration for innovative therapeutic options in oncology. B-cell lymphoma-2 (BCL-2) protein is an anti-apoptotic protein expressed on the clonal plasma cells in patients with multiple myeloma (MM). MM subsets with t (11;14) have overexpression of BCL-2 and can benefit from venetoclax (VEN) when used either alone or in combination with other chemotherapeutic agents with an overall response rate (ORR) ranging from 40% to 100%. The most commonly reported grade >= 3 adverse effects include cytopenias and gastrointestinal side effects. This review highlights the meaningful efficacy and tolerable safety of VEN monotherapy and its combination regimens in the treatment of relapsed refractory MM.




J Hematol. 2021;10(3):89-97
doi: https://doi.org/10.14740/jh844

Keywords


Venetoclax; Multiple myeloma; Relapsed; Refractory

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Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
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