Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera

Mariana Lorenzo, Sofia Grille, Mariana Stevenazzi


Emergence of a new chronic myeloid neoplasm in the setting of a previous one, or their concomitant appearance seems to be a rare event, but plenty of cases have been reported. We describe the case of a patient with JAK2-V617F polycythemia vera, which looses JAK2 clone and develops overt BCR-ABL1 chronic myeloid leukemia after 6 years. Once treatment with tyrosine kinase inhibitors controls BCR-ABL1 clone, JAK2 clone arises again. In this report, we review the literature and discuss the clonal relationship of this event in light of the new molecular data.

J Hematol. 2020;9(1-2):23-29
doi: https://doi.org/10.14740/jh591


Chronic myeloid leukemia; Chronic myeloproliferative neoplasm; BCR-ABL1; JAK2-V617F

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