Diabetes Insipidus as Presenting Manifestation of Waldenstrom's Macroglobulinemia

Saulius Girnius, Laura Dember, Adam Lerner

Abstract


Nephrogenic diabetes insipidus (DI) is characterized by inability of the kidney to concentrate urine due to diminished renal response to vasopressin. We report a patient with diabetes insipidus and hyperviscosity as presenting manifestations of Waldenstrom's macroglobulinemia. After two treatments with plasmapheresis, serum viscosity normalized and the ability to concentrate urine, polyuria, and polydipsia improved. With ongoing chemoimmunotherapy, he has not had a recurrence of DI. Although rare, nephrogenic DI is a complication of hematologic disorders such as Waldenstrom's macroglobulinemia, multiple myeloma and sickle cell anemia.




doi:10.4021/jh31w


Keywords


Diabetes insipidus; Waldenstrom’s macroglobulinemia

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC BY-NC 4.0)



This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.thejh.org    editorial contact: editor@thejh.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
 

© Elmer Press Inc. All Rights Reserved.