Allogeneic Sibling Donor Peripheral Blood Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis-Successful Treatment Despite Severe Phase of the Disease

Monika Dzierzak-Mietla, Miroslaw Markiewicz, Malgorzata Sobczyk-Kruszelnicka, Patrycja Zielinska, Anna Koclega, Slawomira Kyrcz-Krzemien

Abstract


We report a case of a 30-year old patient with Ph-positive chronic myeloid leukemia (CML) in blast crisis in whom short pretreatment with dasatinib was followed by myeloablative conditioning and successful allogeneic hematopoietic stem cell transplantation from HLA-matched sibling-donor. Full donor chimerism has been achieved; no bio-molecular and cytogenetic markers of CML have been detected post-transplant despite lack of further treatment with tyrosine kinase inhibitor. Post-transplant course was complicated by several infections and graft-versus-host disease which were all effectively treated. Patient has limited chronic GVHD and no evidence of CML 20 months after allo-HSCT. Our report proves that successful allo-HSCT can be performed in advanced phase CML and that complete molecular and cytogenetic remission can be maintained post-transplant without further TKI treatment.




doi:10.4021/jh26w


Keywords


Chronic myeloid leukemia; Blast crisis; Allogeneic stem cells transplantation

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC BY-NC 4.0)



This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.thejh.org    editorial contact: editor@thejh.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
 

© Elmer Press Inc. All Rights Reserved.