A Case of Langerhans Cell Histiocytosis With Risk Organ Involvement in a Young Adult

Audrey Kam, Brett Mahon, Reem Karmali


Multisystem Langerhans cell histiocytosis (MS-LCH) is a rare disease for which the standard of care has not been clearly established. We are the first to address frontline and salvage options for the management of an adolescent young adult (AYA) male with MS-LCH with “risk organ” involvement, a population for which there are no therapeutic guidelines. Our 33-year-old male patient presented with MS-LCH with generalized lymphadenopathy, hepatic and splenic involvement. He was initially treated with vinblastine and prednisolone with progression in disease. Our exploration of the literature revealed that salvage options in adults include single-agent chemotherapy, hematopoietic stem cell transplant, imatinib, and vemurafenib and are limited to small case series with questionable efficacy. We opted to use a pediatric regimen with the combination of cladribine and cytarabine and demonstrate that this approach can in fact be effective in an AYA patient.

J Hematol. 2014;3(4):107-111
doi: http://dx.doi.org/10.14740/jh161w


Langerhans cell histiocytosis; Multisystem Langerhans cell histiocytosis; Adolescent young adult; Cladribine; Cytarabine

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.thejh.org    editorial contact: editor@thejh.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.