Prolymphocytic and Richter's Transformation in Peripheral Blood: A Case Report and Review of Literature

Chanchal Rana, Seema Sharma, Mitali Agarwal

Abstract


The indolent course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is occasionally altered by transformation to a histologically distinct, rapidly progressive, and clinically unresponsive hematologic malignant neoplasm, a phenomenon known as Richter's transformation. The most likely site of transformation is enlarging lymph nodes. The malignant cells of Richter's transformation can occasionally be seen in the bone marrow and only very rarely in the peripheral blood. We report an interesting case of CLL which underwent a full spectrum of transformation from classical CLL to prolymphocytic leukemia and finally to Richter's transformation with an unusual feature being a leukemic Richter's transformation, i.e. Richter's transformation in the peripheral blood.




J Hematol. 2014;3(3):86-88
doi: http://dx.doi.org/10.14740/jh121w


Keywords


Chronic lymphocytic leukemia; Prolymohocytic leukemia; Richter’s transformation; Peripheral blood

Full Text: HTML PDF
　

Browse  Journals  

     

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 
 

Journal of Hematology, bimonthly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.                            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC BY-NC 4.0)



This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.thejh.org    editorial contact: editor@thejh.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
 

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.