Potential Benefits of Metformin Use in Sickle Cell Anemia

Nejc Umek, Chiedozie Kenneth Ugwoke

Abstract


Sickle cell anemia (SCA) is one of the most important genetic disorders known to mankind. Even with the impressive advances in medical science, effective treatment and cure remain challenging. Currently available treatments including hydroxyurea, which is the only FDA approved drug for SCA, and hemopoietic stem cell transplantation all have significant limitations, so the search for new therapeutic options continues. Metformin, the traditional antidiabetic drug has recently gained novel attention from accumulating molecular evidence suggesting its pleiotropic effects and new potential applications. Our study of these new understandings of the pharmacodynamics and pleiotropic effects leads us to propose that the drug may be of potential therapeutic benefit in SCA. Our arguments are premised on a logical correlation of the interconnected pathophysiologic mechanisms in SCA with current information on the molecular pharmacodynamics of metformin. We reviewed existing evidence and deduced the diverse effects of metformin of relevant therapeutic significance in SCA, including enhancement of nitric oxide bioavailability, induction of fetal hemoglobin synthesis, attenuation of the inflammatory phenotype and beneficial effects in ischemia/reperfusion injury. Collectively, these considerations lead us to infer that there is reasonable evidence to support potential therapeutic adaptation of metformin in SCA.




J Hematol. 2016;5(2):41-48
doi: http://dx.doi.org/10.14740/jh275w


Keywords


Metformin; Sickle cell anemia; Fetal hemoglobin; eNOS; Inflammation; Ischemia/reperfusion injury

Full Text: HTML PDF
 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     

Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       
       

Journal of Hematology, quarterly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC BY-NC 4.0)



This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.thejh.org    editorial contact: editor@thejh.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
 

© Elmer Press Inc. All Rights Reserved.

IMPORTANT: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!