BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms

Julie Bienertova-Vasku, Petr Bienert, Daniela Kodytkova, Filip Zlamal, Josef Tomandl, Marie Tomandlova, Anna Vasku, Jaroslav Sterba

Abstract


     There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients (Bcp-ALL: 7764 ± 6329 pg/ml, B-cell lymphoma: 2675 ± 1544 pg/ml; P = 0.0268), the circulating levels of BAFF being substantially higher in B-ALl cases. 




doi:10.4021/jh104e

Keywords


B-cell activating factor; Acute lymphoblastic leukaemia; B-cell lymphoma; Paediatric 

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Journal of Hematology, quarterly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.            
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