Figure 1. Overall survival for all patients. Survival was calculated from date of enrollment until date of death from any cause. VSLI: vincristine sulfate liposome injection.
| Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc |
| Journal website https://www.thejh.org |
Original Article
Volume 10, Number 1, February 2021, pages 1-7
A Pilot Phase II Study of the Feasibility and Efficacy of Vincristine Sulfate Liposome Injection in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Figures
Tables
| CR1: first complete remission; HDAC: high-dose cytarabine (Ara-C); IDAC: intermediate-dose Ara-C. | |
| Median age (range) | 78 (41 - 81) |
| Age ≥ 60 years old (%) | 4/5 (80%) |
| Male (%) | 3/5 (60%) |
| No. Caucasian (%) | 5/5 (100%) |
| ECOG performance status | |
| 0 - 1 | 1/5 (20%) |
| 2 | 4/5 (80%) |
| 3 | 0 (0%) |
| Median duration of CR1 in months (range) | 3 (3 - 11) |
| Refractory disease (%) | 2/5 (40%) |
| Previous lines of salvage | |
| 0 | 0 (0%) |
| 1 | 2/5 (40%) |
| 2 | 1/5 (20%) |
| > 2 | 2/5 (40%) |
| Antecedent hematologic disorder | 1/5 (20%) |
| Previous HDAC or IDAC-based salvage | 4/5 (80%) |
| ELN 2017 cytogenetic risk score | |
| Good risk | 0/5 (0%) |
| Intermediate risk | 2/5 (40%) |
| Poor risk | 3/5 (60%) |
| Median %blasts in marrow (range) | 29% (15-49%) |
| Patient number | Cycle | Toxicity | Grade |
|---|---|---|---|
| 01 | 1 | Abdominal pain | 2 |
| 01 | 1 | Bloating | 2 |
| 01 | 1 | Constipation | 2 |
| 01 | 1 | Peripheral sensory neuropathy | 1 |
| 01 | 2 | Abdominal distension | 2 |
| 02 | 1 | Constipation | 1 |
| 02 | 1 | Peripheral sensory neuropathy | 1 |
| 03 | 1 | Abdominal distension | 1 |
| 03 | 1 | Anorexia | 2 |
| 03 | 1 | Bloating | 1 |
| 03 | 1 | Constipation | 2 |
| 03 | 1 | Nausea | 2 |
| 03 | 1 | Peripheral sensory neuropathy | 1 |
| 03 | 1 | Vomiting | 1 |
| 04 | 1 | Abdominal pain | 2 |
| 04 | 1 | Nausea | 3 |
| 05 | 1 | Abdominal pain | 2 |
| 05 | 1 | Constipation | 1 |
| 05 | 1 | Nausea | 1 |
| 05 | 1 | Peripheral sensory neuropathy | 1 |
| 05 | 1 | Rash maculo-papular | 1 |