Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
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Case Report

Volume 10, Number 1, February 2021, pages 25-29

Histologic Transformation in an Untreated Waldenstrom’s Macroglobulinemia After 14 Years: Case Report and Review of the Literature

Figures

Figure 1.
Figure 1. Diagram of histologic transformation course. WM: Waldenstrom’s macroglobulinemia; LDH: lactate dehydrogenase.
Figure 2.
Figure 2. Pathology slides. (a) Bone marrow biopsy showing sheets of small atypical lymphoid cells and occasional plasma cells diffusely involving the bone marrow, consistent with Waldenstrom’s macroglobulinemia (H&E, × 40). (b) Bone marrow biopsy showing clusters of large malignant lymphoid cells in a background of bone marrow elements post-histologic transformation (H&E, × 20). (c) Lymph node biopsy showing large malignant lymphoid cells with centroblastic morphology. Histologic transformation to large cell lymphoma (H&E, × 40). H&E: hematoxylin and eosin.