Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
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Short Communication

Volume 9, Number 3, September 2020, pages 79-83

Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia


Figure 1.
Figure 1. Kaplan-Meier estimates of PFS. PFS: progression-free survival.


Table 1. Patient Baseline Characteristics
Patient numberAge (years)GenderComorbiditiesMutations on FISHPrior regimens (number)Most recent regimen prior to enrollmentResponse to most recent regimen
BR: bendamustine/rituximab; FCR: fludarabine/cyclophosphamide/rituximab; CR: complete response; PR: partial response; CAD: coronary artery disease; CHF: congestive heart failure; CVD: cerebrovascular disease; DM2: diabetes mellitus type 2; HTN: hypertension; SVT: supraventricular tachycardia; SD: stable disease; FISH: fluorescence in situ hybridization.
175MaleDM2, CVD, HTNDel (17p)4RituximabCR
254MaleSVTDel (13q)1RituximabPR
359FemaleNoneDel (17p)/trisomy 121FCRCR
467MaleDM2Del (17p)3RituximabPR
571MaleHTN, CAD, hypothyroidismDel (13q)3RituximabPR
676MaleHTN, atrial fibrillationDel (11q)/del (13q)1Fludarabine/rituximabCR
750MaleNoneDel (13q)4BRSD
862MaleNoneDel (11q)/del (13q)5IdelalisibPR
971MaleCVD, CAD, CHF, prostate cancerDel (11q)/del (13q)1FCR lightPR
1064MaleHTN, hypothyroidism, hyperprolactinemiaDel (13q)1RituximabCR
1164FemaleNoneTrisomy 121RituximabCR
1261MaleNoneDel (13q)/del (17p)1BRPR


Table 2. Complement Levels and Activity
Patient numberBaseline C3 (mg/dL)Baseline C4 (mg/dL)Baseline CH50 (U/mL)Week 2 C3 (%Δ)aWeek 2 C4 (%Δ)Week 2 CH50 (%Δ)Best response
aPercent change from baseline; bLow complement values (normal range: C3: 92 - 210 mg/dL, C4: 18 - 56 mg/dL, CH50: 60 - 144 U/mL). CR: complete response; PR: partial response.
115442111125 (-19)22 (-48)105 (-5)PR
21132912787 (-23)4.9b (-83)0b (-127)PR
31483113699 (-33)4.9b (-84)35b (-74)CR
415345193128 (-16)20 (-56)110 (-43)CR
51333077114 (-14)7b (-77)58b (-25)PR
689b4.9b17b79 (-11)4.9b (0)1b (-94)PR
788b14b7985 (-3)4.9b (-64)32b (-59)PD
818745145134 (-22)9b (-80)52b (-64)PD
91252695118 (-6)17b (-35)111 (+17)PR
1014131145143 (+1)25 (-19)114 (-20)PR
1112824146107 (-16)5b (-79)15b (-90)PR
121002011784 (-16)4.9b (-75)40b (-66)PR