Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website https://www.thejh.org

Original Article

Volume 9, Number 3, September 2020, pages 62-70

Clinical Impact of Percentage of Natural Killer Cells and Natural Killer-Like T Cell Population in Acute Myeloid Leukemia

Figures

Figure 1.
Figure 1. Natural killer (NK) and natural killer-like T (NKT) cells with survival.
Figure 2.
Figure 2. Natural killer (NK) and natural killer-like T (NKT) cells with risk stratification.
Figure 3.
Figure 3. Survival of cases in according to cutoff level of natural killer-like T (NKT) cells.
Figure 4.
Figure 4. Correlation between risk stratification and duration of survival.
Figure 5.
Figure 5. Overall survival of studied acute myeloid leukemia cases.

Tables

Table 1. Demographic Data of Studied AML Cases in Relation to Control
 
Demographic dataCases (N = 50)
AML: acute myeloid leukemia.
Age
  Mean44.7
  Standard deviation15.36
Gender
  Male, n (%)25 (50)
  Female, n (%)25 (50)

 

Table 2. Laboratory Data of the Studied AML Cases at Presentation
 
ParametersNumber of cases (N = 50)
N%
AML: acute myeloid leukemia; FISH: fluorescent in situ hybridization.
WHO classification of AML cases
  AML with recurrent cytogenetics
    AML with t(8;21)48.0
    AML with inv1636.0
    Acute promyelocytic leukemia with PML/RARA714.0
    AML with t(6;9)12.0
    AML with bi-allelic mutation of CEPBA12.0
    AML without maturation714.0
    AML with maturation1224.0
    Acute myelomonocytic leukemia1020.0
    Acute monoblastic/monocytic leukemia36.0
    Pure erythroid leukemia24.0
Conventional karyotyping
  Normal4386.0
  47,xy,+848.0
  47,xy,+912.0
  46,xy,-912.0
  46,xy,t(6:9)12.0
Cancer cytogenetics (FISH)34
  Positive
    inv1636.0
    t(15;17)714.0
    t(8;21)48.0
  Negative2040
  Not available1632

 

Table 3. Response to Induction Treatment in Studies AML Patients
 
Response to induction treatmentNumber of patients (N = 44)
N%
AML: acute myeloid leukemia; CR: complete remission; PR: partial response.
CR1734.0
PR826.0
Refractory510.0
Died in aplasia1428.0

 

Table 4. NK Cells and NKT Cells With Response to Induction Treatment
 
Response to inductionNK cellsNKT cells
MedianRangeMedianRange
NK: natural killer; NKT: natural killer-like T; CR: complete remission; PR: partial response.
CR0.43500.00 - 1.900.0260.01 - 0.390
PR0.53250.00 - 1.020.0950.004 - 0.270
Refractory0.880.00 - 2.560.0500.020 - 0.210
Died after induction0.770.08 - 3.700.0900.00 - 2.01

 

Table 5. Comparison of P Values Between Groups
 
Response to induction groupsNK cellsNKT cells
NK: natural killer; NKT: natural killer-like T; CR: complete remission; PR: partial response.
CR vs. PR0.8620.63
CR vs. refractory cases0.290.33
CR vs. died after induction0.430.56

 

Table 6. Comparison of P Values According to Risk Stratification
 
Risk groupsNK cellsNKT cells
NK: natural killer; NKT: natural killer-like T.
Low vs. intermediate risk0.290.39
Low vs. high risk0.0090.05
Intermediate vs. high risk0.060.12