Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
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Case Report

Volume 7, Number 2, May 2018, pages 79-82

A Rare t(5;11)(q35;q13) Translocation in an Elderly Patient With Acute Myeloid Leukemia With Maturation: A Case Report

Figures

Figure 1.
Figure 1. Bone marrow cells seen at the diagnosis of leukemia. Low frequencies of dyserythropoiesis and dysmegakaryopoiesis were observed. (a-c) Leukemic cells (May-Giemsa staining); abundant granules were occasionally observed (b); (d, e) blasts that were positively and negatively stained for myeloperoxidase, respectively; (f) a binuclear erythroblast (May-Giemsa staining); (g-i) megakaryocytes (May-Giemsa staining); (g) a small mononuclear megakaryocyte; (h) a trinuclear megakaryocyte; (i) a megakaryocyte containing multiple separate, round nuclei.
Figure 2.
Figure 2. (a) G-band karyotype analysis performed at the diagnosis of leukemia revealed the following karyotype: 46,XX,t(5;11)(q35;q13). The arrows indicate derivative chromosomes. (b) Partial spectral karyotyping of the patient’s metaphase spread after spectrum-based classification (left, counterstained with 4’,6-diamino-2-phenylindole dihydrochloride; right, spectral karyotyping).

Table

Table 1. Cases of Acute Myeloid Leukemia Involving t(5;11)(q35;q13)
 
AuthorAge/sexDxKaryotypeaImmunophenotypeSubsequent therapy and clinical course
NR: not reported; IDR: idarubicin; CA: cytosine arabinoside; ETP: etoposide; DNR: daunorubicin; MIT: mitoxantrone; HU: hydroxyurea; SCT: stem cell transplantation; HLA: human leukocyte antigen. aExpect for that for our case, the karyotype descriptions are shown according to the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer [5].
Leverger et al [1]14/MM546,XY,t(5;11)(q35;q13)/46,idem,del(9)(q12q32)NRNR
Itoh et al [2]28/MM446,XY,t(5;11)(q35;q13)NRNo remission was obtained in spite of various therapy; 18 months of survival
Wang et al [3]19/MM246,XY,t(5;11)(q35;q13)CD13+, CD34+, CD33+, CD19+, CD15+, HLA-DR+IDR/CA, MIT/ETP/CA (induction failure); returned to the nearest hospital with oral HU
De Oliveira et al [4]30/MM246,XY,t(5;11)(q35;q13)CD13+, CD34+, CD33+, CD19-, CD117-, HLA-DR+DNR/CA twice (partial remission); received allogeneic SCT from HLA-identical sister
Present case85/FM246,XX,t(5;11)(q35;q13)[8]/46,XX[12]CD13+, CD34+, CD33+, CD7+, CD56+, HLA-DR+Palliative care alone; died of intracranial hemorrhage (6 months)