Figure 1. Algorithm for management of thrombocytopenia.
| Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc |
| Journal website http://www.thejh.org |
Review
Volume 1, Number 2-3, June 2012, pages 44-53
Thrombocytopenia in Adults: Review Article
Figure
Tables
| 1. Artificial thrombocytopenia |
| a. Forming of platelet which relevant to anticoagulant immunoglobulin (pseudothrombocytopenia) |
| b. Platelet satellism |
| c. Giant platelets |
| 2. Decreased product thrombocyte |
| a. Megakaryocyte hypoplasia or suppression |
| b. Ineffective thrombopoiesis |
| c. Defeat in mechanism which are controlling thrombopoiesis |
| d. Herediter trombositopenia |
| 3. Increased platelet destruction |
| a. Immunologic |
| - Autoimmune |
| - Primer (Immune thrombocytopenia) |
| - Seconder (Infections, pregnancy, collagen tissue diseases, lymphoproliferative diseases, drugs) |
| - Alloimmun |
| - Neonatal thrombocytopenia |
| - Post-transfusion purpura |
| b. Nonimmunologic |
| - Thrombotic microanjiopaties |
| - Disseminated intravascular coagulation |
| - Thrombotic thrombocytopenic purpura |
| - Hemolytic-uremic syndrome |
| - Abnormal vascular relevant to the surface of thrombocytopenia |
| - Others (infection, massif blood transfusion) |
| 4. Abnormal platelet distribution |
| a.The disease that capture spleen (neoplasia,congestive, infiltration) |
| b. Hypothermyia |
| Heparin | Anti-epileptic drugs |
| · Regular unfractionated | · Carbamazepine |
| · Low molecular weight | · Phenytoin |
| GPIIb/IIIa inhibitors | Anti-histamines |
| · Abciximab | · Antazoline |
| · Eptifibatide | · Chlorpheniramine |
| · Tirofiban | |
| Anti-inflamatory drugs | Illicit drugs |
| · Acetaminofphen | · Cocaine |
| · Salicylates (Aspirin, Diflunisal, Aminosalicylate, Sulfosalazine) | · Heroine |
| · Diclofenac | |
| · Fenoprofen and iboprofen | |
| · Indomethacin | |
| · Meclofenamate | |
| · Mefanimic acid | |
| · Naproxen | |
| · Oxyphenylbutazone | |
| · Phenylbutazone | |
| · Piroxicam | |
| · Sulindac | |
| Cardiac medications and diuretics | Miscellanous drugs |
| · Digoxin | · Quinine and quinidine |
| · Digitoxin | · Gold salts |
| · Amiodarone | · Valproic acid |
| · Procainamide | · Measales-mumps-rubella vaccine |
| · Alprenolol | · Tamoxifen |
| · Oxprenolol | · Actinomycin-D |
| · Captopril | · Aminoglutethimide |
| · Diazoxide | · Danazole |
| · Alpha-methyldopa | · Desferrioxamine |
| · Acetazolamide | · Levamizole |
| · Chlorthiazide | · Lidocaine |
| · Furosemide | · Morphine |
| · Hydrochlorthiazide | · Papaverine |
| · Spironolactone | · Ticlopidine |
| · Sulfonylurea drugs | |
| · Chlorpropamide | |
| · Glibenclamide | |
| · Iodinated contrast agents | |
| · Retinoids, isotretinoin | |
| · Etretinate | |
| Benzodiazepines | Antimony containing drugs |
| · Diazepam | · Stibophen |
| · Sodium stibogluconate | |
| H2 antagonists | Antidepressants |
| · Cimetidine | · Amitriptyline |
| · Ranitidine | · Mianserine |
| · Desipramine |