Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website http://www.thejh.org

Review

Volume 1, Number 2-3, June 2012, pages 44-53


Thrombocytopenia in Adults: Review Article

Figure

Figure 1.
Figure 1. Algorithm for management of thrombocytopenia.

Tables

Table 1. Classification of Thrombocytopenia
 
1. Artificial thrombocytopenia
  a. Forming of platelet which relevant to anticoagulant immunoglobulin (pseudothrombocytopenia)
  b. Platelet satellism
  c. Giant platelets
2. Decreased product thrombocyte
  a. Megakaryocyte hypoplasia or suppression
  b. Ineffective thrombopoiesis
  c. Defeat in mechanism which are controlling thrombopoiesis
  d. Herediter trombositopenia
3. Increased platelet destruction
  a. Immunologic
    - Autoimmune
    - Primer (Immune thrombocytopenia)
    - Seconder (Infections, pregnancy, collagen tissue diseases, lymphoproliferative diseases, drugs)
    - Alloimmun
    - Neonatal thrombocytopenia
    - Post-transfusion purpura
  b. Nonimmunologic
    - Thrombotic microanjiopaties
    - Disseminated intravascular coagulation
    - Thrombotic thrombocytopenic purpura
    - Hemolytic-uremic syndrome
    - Abnormal vascular relevant to the surface of thrombocytopenia
    - Others (infection, massif blood transfusion)
4. Abnormal platelet distribution
  a.The disease that capture spleen (neoplasia,congestive, infiltration)
  b. Hypothermyia

 

Table 2. Drugs Commonly Associated With Thrombocytopenia
 
HeparinAnti-epileptic drugs
· Regular unfractionated· Carbamazepine
· Low molecular weight· Phenytoin
GPIIb/IIIa inhibitorsAnti-histamines
· Abciximab· Antazoline
· Eptifibatide· Chlorpheniramine
· Tirofiban
Anti-inflamatory drugsIllicit drugs
· Acetaminofphen· Cocaine
· Salicylates (Aspirin, Diflunisal, Aminosalicylate, Sulfosalazine)· Heroine
· Diclofenac
· Fenoprofen and iboprofen
· Indomethacin
· Meclofenamate
· Mefanimic acid
· Naproxen
· Oxyphenylbutazone
· Phenylbutazone
· Piroxicam
· Sulindac
Cardiac medications and diureticsMiscellanous drugs
· Digoxin· Quinine and quinidine
· Digitoxin· Gold salts
· Amiodarone· Valproic acid
· Procainamide· Measales-mumps-rubella vaccine
· Alprenolol· Tamoxifen
· Oxprenolol· Actinomycin-D
· Captopril· Aminoglutethimide
· Diazoxide· Danazole
· Alpha-methyldopa· Desferrioxamine
· Acetazolamide· Levamizole
· Chlorthiazide· Lidocaine
· Furosemide· Morphine
· Hydrochlorthiazide· Papaverine
· Spironolactone· Ticlopidine
· Sulfonylurea drugs
· Chlorpropamide
· Glibenclamide
· Iodinated contrast agents
· Retinoids, isotretinoin
· Etretinate
BenzodiazepinesAntimony containing drugs
· Diazepam· Stibophen
· Sodium stibogluconate
H2 antagonistsAntidepressants
· Cimetidine· Amitriptyline
· Ranitidine· Mianserine
· Desipramine