Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website http://www.thejh.org

Original Article

Volume 4, Number 2, June 2015, pages 164-170

Treatment of Anemia Owing to Increased Menstrual Blood Loss: Activity of Physiological Modulators

Tables

Table 1. Quantity of Essential Amino Acids and Iron in Hb
 
Essential amino acid and iron% in HbQuantity (mg) in 0.71 g Hb
Histidine7.151
Leucine12.891
Lysine8.258
Methionine1.410
Phenylalanine5.539
Threonine6.445
Tryptophan1.410
Valine12.387
Fe0.3462.5

 

Table 2. Timetable of the Single Blind Trial Conducted on Anemic Women With Very Abundant/Excessive Menstrual Flow
 
Menstrual cycleTreatmentsMeasures
FirstNoFlow
SecondPlaceboFlowCell countHbIron variables
ThirdFormulaFlowCell countHbIron variables

 

Table 3. Physiological Modulators Content in the Formula (F)
 
Productmg
aGiven as 21.6 mg of iron gluconate dehydrate. bCorresponding between 20% and 35% of NRV (nutritional reference value) by the European Food Safety Agency.
Histidine51
Leucine91
Lysine58
Methionine10
Phenylalanine39
Threonine45
Tryptophan10
Valine87
Fea2.5
Ascorbic acid15
Vit B1b0.35
Vit B2b0.40
Nicotinamideb4.5
Vit B6b0.5
Folic acidb0.05
Vit B12b0.0005

 

Table 4. List of the Variables Measured After 28 Days of Treatment With Placebo and After Treatment With F: average values ± SD
 
VariableMeasureAfter placeboAfter FDunnett
AgeYears34.9 ± 4.20
Body weightkg53.8 ± 3.16
Hbg/dL10.2 ± 1.2912.6 ± 0.66P < 0.01
Ht%35.8 ± 3.0539.8 ± 4.20P < 0.01
Feμg/dL50 ± 8.965.3 ± 9.30p < 0.01
Transferrinmg/dL309 ± 33.0338 ± 34.2P < 0.01
Ferritinng/mL101 ± 22.0124 ± 28.0P < 0.01
RBC1063.96 ± 0.2464.30 ± 2.73P < 0.01
Reticulocytes%1.3 ± 0.821.9 ± 0.65P < 0.01
Platelets103126.7 ± 26.80155.6 ± 26.82P < 0.01
MCVfL90 ± 8.693 ± 12.2P < 0.01
MCHpg26 ± 3.129 ± 2.7P < 0.01
Menstrual flowScore5.1 ± 1.313.1 ± 1.10P < 0.01