J Hematol

Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc

Journal website http://www.thejh.org

Original Article

Volume 3, Number 1, March 2014, pages 1-9

Tissue Doppler Echocardiography in Detection of Myocardial Iron Overload Confirmed by Cardiac MRI in Patients With Beta Thalassemia Major: A Meta-Analysis

Figures

Figure 1. Flowchart of study selection.

Figure 2. Forest plot of comparison: 1 TDI parameters, outcome: 1.1 LVEF (%) compared to CMR T2* in detecting myocardial iron overload.

Figure 3. Forest plot of comparison: 1 LVEF (%), outcome: 1.2 Tei index compared to CMR T2* in detecting myocardial iron overload.

Figure 4. Forest plot of comparison: 1 TDI parameters, outcome: 1.3 E/A ratio compared to CMR T2* in detecting myocardial iron overload.

Figure 5. Forest plot of comparison: 1 TDI parameters, outcome: 1.4 deceleration time (ms) compared to CMR T2* in detecting myocardial iron overload.

Figure 6. Forest plot of comparison: 2 TDI parameters compared to CMR T2* in iron overloaded thalassemia patients, outcome: 2.1 TDI parameters.

Tables

**Table 1.** Demographics
Authors	N	Mean age of case group	Mean age of control group	Sex, % (male/female) case group	Sex, % (male/female) control group	Average no. of BT/year, n (%)	Average no. of years receiving BT
Dabirian et al (2012)	50	5.5 ± 9.25		38/62		9.1 ± 4.2	-
Aessopos et al (2006)	142	29.96 ± 5.91		49/51		-	12
Barzin et al (2012)	33	-		48/52		-	15
Aypar et al (2010)	33	18 ± 6	17 ± 6	42/58	40/60	-	17 ± 6
Rodrigues et al (2013)	18	18.3 ± 10.6	18.1 ± 7.27/18.6 ± 10.6	15/3	15/3/15/3	-	-

**Table 2.** Characteristics of Included Studies
Authors	Year	Design	Country	No. of cases	No. of control	Diagnostic methods
Daibiran et al (2007)	2012	Cross-sectional prospective	Iran	50	-	TDI and T2*MR
Aessopos et al (2006)	2006	Cross-sectional prospective	Greece	142	-	2D echo, M-mode echo, TDI and T2*MR
Barzin et al (2011)	2012	Cross-sectional prospective	Iran	33	-	TDI and T2*MR
Aypar et al (2010)	2010	Case-control prospective	Turkey	33	20	TDI and T2*MR
Rodrigues et al (2013)	2013	Case-control prospective	Brazil	18	36 (18/18)	2D echo Doppler and TDI