Diabetes Insipidus as Presenting Manifestation of Waldenstrom’s Macroglobulinemia

Saulius Girnius, Laura Dember, Adam Lerner

Abstract


    Nephrogenic diabetes insipidus (DI) is characterized by inability of the kidney to concentrate urine due to diminished renal response to vasopressin. We report a patient with diabetes insipidus and hyperviscosity as presenting manifestations of Waldenstrom’s macroglobulinemia. After two treatments with plasmapheresis, serum viscosity normalized and the ability to concentrate urine, polyuria, and polydipsia improved. With ongoing chemoimmunotherapy, he has not had a recurrence of DI. Although rare, nephrogenic DI is a complication of hematologic disorders such as Waldenstrom’s macroglobulinemia, multiple myeloma and sickle cell anemia.




doi:10.4021/jh31w


Keywords


Diabetes insipidus; Waldenstrom’s macroglobulinemia

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Journal of Hematology, quarterly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.            
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