Allogeneic Sibling Donor Peripheral Blood Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis-Successful Treatment Despite Severe Phase of the Disease

Abstract

We report a case of a 30-year old patient with Ph-positive chronic myeloid leukemia (CML) in blast crisis in whom short pretreatment with dasatinib was followed by myeloablative conditioning and successful allogeneic hematopoietic stem cell transplantation from HLA-matched sibling-donor. Full donor chimerism has been achieved; no bio-molecular and cytogenetic markers of CML have been detected post-transplant despite lack of further treatment with tyrosine kinase inhibitor. Post-transplant course was complicated by several infections and graft-versus-host disease which were all effectively treated. Patient has limited chronic GVHD and no evidence of CML 20 months after allo-HSCT. Our report proves that successful allo-HSCT can be performed in advanced phase CML and that complete molecular and cytogenetic remission can be maintained post-transplant without further TKI treatment.




doi:10.4021/jh26w