Allogeneic Sibling Donor Peripheral Blood Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis-Successful Treatment Despite Severe Phase of the Disease

Monika Dzierzak-Mietla, Miroslaw Markiewicz, Malgorzata Sobczyk-Kruszelnicka, Patrycja Zielinska, Anna Koclega, Slawomira Kyrcz-Krzemien

Abstract


     We report a case of a 30-year old patient with Ph-positive chronic myeloid leukemia (CML) in blast crisis in whom short pretreatment with dasatinib was followed by myeloablative conditioning and successful allogeneic hematopoietic stem cell transplantation from HLA-matched sibling-donor. Full donor chimerism has been achieved; no bio-molecular and cytogenetic markers of CML have been detected post-transplant despite lack of further treatment with tyrosine kinase inhibitor. Post-transplant course was complicated by several infections and graft-versus-host disease which were all effectively treated. Patient has limited chronic GVHD and no evidence of CML 20 months after allo-HSCT. Our report proves that successful allo-HSCT can be performed in advanced phase CML and that complete molecular and cytogenetic remission can be maintained post-transplant without further TKI treatment.




doi:10.4021/jh26w


Keywords


Chronic myeloid leukemia; Blast crisis; Allogeneic stem cells transplantation

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Journal of Hematology, quarterly, ISSN 1927-1212 (print), 1927-1220 (online), published by Elmer Press Inc.            
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